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李春权

v  1979年9月出生,哈尔滨医科大学,大庆校区医学信息学系,系副主任(正科级)、博士,副教授,硕士研究生导师。大庆市劳动模范获得者,哈尔滨医科大学青年五四奖章获得者,于维汉院士杰出青年培养基金获得者,哈尔滨医科大学十大青年科技人才奖获得者,黑龙江省优秀博士论文获得者,人民卫生出版社出版《生物信息学理论与医学实践》一书担任编委,全国性生物信息学培训班教师(共三期),全国生物信息暑期学校培训教师,全国生物信息骨干教师培训班讲座教师。研究方向是“复杂疾病相关的代谢通路重构、分析和识别”。

v  迄今已累计发表SCI研究论文43篇。第1作者、并列第1作者论文或通讯作者论文30篇,其中SCI影响因子>5的论文13篇。分别发表在英国牛津出版集团出版的《Nucleic Acids Research》(三篇)、《Bioinformatics》、英国自然出版集团出版的自然系列子刊《SCIENTIFIC REPORTS》、《Human Mutation》、《BMC bioinformatics》、《BioMed Research International》、《Gene》、《Journal of Biomedical Informatics》、《 PLoS ONE》、《Asian Pacific Journal of Cancer Prevention: APJCP》等杂志上。作为项目负责人,承担国家自然科学基金青年面上项目、国家自然科学基金青年基金项目、国家教育部高等学校博士点学科专项科研基金项目、于维汉院士杰出青年培养基金、黑龙江省自然科学基金面上项目、黑龙江省教育厅科学技术研究项目等课题。研究成果分别获得黑龙江省自然科学技术学术成果奖一等奖(排名第1)和中华医学科技奖三等奖(排名第5)。开发的SubpathwayMiner等子通路识别相关软件平台被高影响力的顶级综述杂志《Nature reviews cancer》(SCI影响因子=37.9)所引用,并且被列入杂志论文的通路识别软件列表,推荐给各国的癌症研究人员使用该系统。同时被列入的通路识别软件GSEA、SPIA等均为国际最著名的通路识别软件之一,表明SubpathwayMiner软件平台已进入国际主流通路识别软件行列。SubpathwayMiner等相关软件平台2011年也被美国化学综述杂志《CHEMICAL REVIEWS》(SCI影响因子=40.2)、美国年度综述杂志《ANNUAL REVIEWS》(SCI影响因子=21.6)两大国际顶级杂志所引用和推荐研究人员使用。另外,该平台也多次被国际专业领域高影响力的杂志,例如生物信息学领域顶级综述杂志《Briefings in Bioinformatics》、药物领域高影响力专刊《DRUG DISCOVERY TODAY》、《Clinical Pharmacoligy&Therapeutics》等引用或报道。目前SubpathwayMiner相关分析平台已被美国、英国、德国、日本、加拿大、韩国等几十个国家的研究机构使用。

教育经历(按时间倒排序):

v  2009/09-2012/07,哈尔滨医科大学,生物物理学专业(生物信息学方向),博士。

v  2003/09-2005/07,哈尔滨工业大学,计算机科学与技术专业,硕士。

v  1998/09-2002/07,大连海事大学,轮机工程专业,学士。

研究工作经历(科研与学术工作经历,按时间倒序排序):

v  2012/10 - 至今,哈尔滨医科大学,生物信息科学与技术学院/大庆校区医学信息学院,副教授。

v  2009/10-2012/09,哈尔滨医科大学,生物信息科学与技术学院,讲师。

v  2005/08-2009/09,哈尔滨医科大学,生物信息科学与技术学院,助教。

主持或参加科研项目及人才计划项目情况(按时间倒序排序):

v  国家自然科学基金面上项目,81572341、食管癌中非编码RNA调控的代谢通路高异常区域识别及其分子互作机制、2016/1-2019/12、67.8万元、在研、主持。

v  黑龙江省自然科学基金面上项目,F2016031、2016/07-2019/07、整合microRNA与mRNA表达谱识别复杂疾病风险通路、6万元、在研、主持。

v  国家自然科学基金青年项目,31401127、基于通路内部结构与通路间crosstalk识别复杂疾病风险通路的研究、2015/1-2017/12、20万元、在研、参加。

v  于维汉院士杰出青年培养基金项目,无、无、2014/07-2017/06、30万元、在研、主持。

v  国家自然科学基金青年项目,31200996、整合高通量基因、代谢子和通路结构信息的癌症风险代谢通路区域系统识别、2013/1-2015/12、22万元、在研、主持。

v  黑龙江省教育厅项目,12531295、复杂疾病风险代谢通路整合识别方法研究,2013/1-2015/12、2万元、在研、主持。

v  国家教育部高等学校博士点学科专项科研基金项目,20102307120027,疾病代谢子通路融合挖掘及网络分析方法研究、2011/01-2013/12、3.6万元、已结题、主持。

v  黑龙江省研究生创新基金(重点)项目,YJSCX2011-316HLJ、融合基因组和代谢组进行复杂疾病风险代谢通路区域精细识别、2011/9-2012/7、5万元、已结题、申请人。

v  国家自然科学基金重大研究计划项目,91029717、融合组学挖掘非可控性炎症向癌症转化的分子机制、2011/1-2013/12、60万、已结题、参加。

v  国家自然科学基金面上项目,30871394、复杂疾病关联的miRNA-mRNA功能模块识别的信息融合方法研究、2009/1-2011/12、33万元、已结题、参加。

发表SCI研究论文的目录(标记#者为共同第一作者,标记*者为通讯或共同通讯作者)

2009年:

1.        Li C (李春权), Li X*, Miao Y, Wang Q, Jiang W, Xu C, Li J, Han J, Zhang F, Gong B, Xu L. SubpathwayMiner: a software package for flexible identification of pathways. Nucleic acids research. 2009;37(19):e131.SCI影响因子IF=9.2

2011年:

2.        Li J#, Gong B#, Chen X, Liu T, Wu C, Zhang F, Li C (李春权), Li X*, Rao S*. DOSim: an R package for similarity between diseases based on Disease Ontology. BMC bioinformatics. 2011;12:266.

3.        Xu J#, Li C#, Li Y, Lv J, Ma Y, Shao T, Xu L, Wang Y, Du L, Zhang Y, Jiang W, Li C (李春权), Xiao Y, Li X*. MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features. Nucleic acids research. 2011;39(3):825-836.SCI影响因子IF=9.2

4.        Li X#*, Li C (李春权)#, Shang D#, Li J, Han J, Miao Y, Wang Y, Wang Q, Li W, Wu C, Zhang Y, Li X, Yao Q. The implications of relationships between human diseases and metabolic subpathways. PLoS One. 2011;6(6):e21131.

5.        Qiao W, Cheng H, Li C (李春权), Jin H, Yang S, Li X, Zhang Y*. Identification of pathways involved in paclitaxel activity in cervical cancer. Asian Pacific journal of cancer prevention : APJCP. 2011;12(1):99-102.

2012年:

6.        Qiu F#, Xu Y#,*, Li K#, Li Z#, Liu Y#, DuanMu H, Zhang S, Chang Z, Zhou Y, Zhang R, Li C (李春权), Zhang Y, Liu M, Li X. CNVD: text mining-based copy number variation in disease database. Human mutation. 2012;33(11):E2375-81.SCI影响因子IF=6.0

7.        Li C (李春权)#, Han J#, Shang D#, Li J, Wang Y, Zhang Y, Yao Q, Zhang C, Li K*, Li X*. Identifying disease related sub-pathways for analysis of genome-wide association studies. Gene. 2012;503(1):101-109.

8.        Li C (李春权)#, Shang D#, Wang Y#, Li J, Han J, Wang S, Yao Q, Wang Y, Zhang Y, Zhang C, Xu Y, Jiang W, Li X*. Characterizing the network of drugs and their affected metabolic subpathways. PLoS One. 2012;7(10):e47326.

2013年:

9.        Li C (李春权)#, Han J#, Yao Q#, Zou C, Xu Y, Zhang C, Shang D, Zhou L, Sun Z, Li J, Zhang Y, Yang H, Gao X*, Li X*. Subpathway-GM: identification of metabolic subpathways via joint power of interesting genes and metabolites and their topologies within pathways. Nucleic acids research. 2013;41(9):e101.SCI影响因子IF=9.2

10.    Liu W#, Li C (李春权)#, Xu Y, Yang H, Yao Q, Han J, Shang D, Zhang C, Su F, Li X, Xiao Y, Zhang F, Dai M*, Li X*. Topologically inferring risk-active pathways toward precise cancer classification by directed random walk. Bioinformatics. 2013;29(17):2169-2177.SCI影响因子IF=5.7

11.    Wu B#, Luo L#, Li C (李春权), Xie J, Du Z, Wu J, Zhang P, Xu L*, Li E*. Comprehensive bioinformation analysis of the mRNA profile of fascin knockdown in esophageal squamous cell carcinoma. Asian Pacific journal of cancer prevention : APJCP. 2013;14(12):7221-7227.

12.    Shi H, Xu J, Zhang G, Xu L, Li C (李春权), Wang L, Zhao Z, Jiang W, Guo Z*, Li X*. Walking the interactome to identify human miRNA-disease associations through the functional link between miRNA targets and disease genes. BMC systems biology. 2013;7:101.

13.    Zhang F#, Gao B#, Xu L, Li C (李春权), Hao D, Zhang S, Zhou M, Su F, Chen X, Zhi H, Li X*. Allele-specific behavior of molecular networks: understanding small-molecule drug response in yeast. PLoS One. 2013;8(1):e53581.

14.    Wu B#, Li C (李春权)#, Zhang P, Yao Q, Wu J, Han J, Liao L, Xu Y, Lin R, Xiao D, Xu L, Li E*, Li X*. Dissection of miRNA-miRNA interaction in esophageal squamous cell carcinoma. PLoS One. 2013;8(9):e73191.

2014年:

15.    Wu B#, Li C(李春权)#, Du Z, Yao Q, Wu J, Feng L, Zhang P, Li S, Xu L*, Li E*. Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma. Sci Rep. 2014 Jun 23;4:5403.SCI影响因子IF=5.2

16.    Li F#, Xu Y#, Shang D, Yang H, Liu W, Han J, Sun Z, Yao Q, Zhang C, Ma J, Su F, Feng L, Shi X, Zhang Y, Li J, Gu Q, Li X*, Li C (李春权)*. MPINet: metabolite pathway identification via coupling of global metabolite network structure and metabolomic profile. Biomed Res Int. 2014;2014:325697.

17.    Wu B#, Li C (李春权)#, Du Z, Zhou F, Xie J, Luo L, Wu J, Zhang P, Xu L*, Li E*. Functional analysis of the mRNA profile of neutrophil gelatinaseassociated lipocalin overexpression in esophageal squamous cell carcinoma using multiple bioinformatic tools. Mol Med Rep. 2014 Oct;10(4):1800-1812.

18.    Zhang C#, Li C (李春权)#, Li J#, Han J, Shang D, Zhang Y, Zhang W, Yao Q, Han L, Xu Y, Yan W, Bao Z, You G, Jiang T*, Kang C*, Li X*. Identification of miRNA-mediated core gene module for glioma patient prediction by integrating high-throughput miRNA, mRNA expression and pathway structure. PLoS One. 2014 May 8;9(5):e96908.

19.    Shang D#, Li C (李春权)#, Yao Q#, Yang H, Xu Y, Han J, Li J, Su F, Zhang Y, Zhang C, Li D*, Li X*. Prioritizing Candidate Disease Metabolites Based on Global Functional Relationships between Metabolites in the Context of Metabolic Pathways. PLoS One. 2014 Aug 25;9(8):e104934.

20.    Li J, Li C (李春权), Han J, Zhang C, Shang D, Yao Q, Zhang Y, Xu Y, Liu W, Zhou M, Yang H, Su F, Li X*. The detection of risk pathways, regulated by miRNAs, via the integration of sample-matched miRNA-mRNA profiles and pathway structure. J Biomed Inform. 2014 June;49:187-197.

21.    Chen S#, Li C (李春权)#, Wu B, Zhang C, Liu C, Lin X, Wu X, Sun L, Chen B, Zhong Z*, Xu L*, Li E. Identification of differentially expressed genes and their subpathways in recurrent versus primary bone giant cell tumors. Int J Oncol. 2014 Sep;45(3):1133-1142.

22.    Li J#, Zhang Y#, Wang Y#, Zhang C, Wang Q, Shi X, Li C (李春权), Zhang R*, Li X*. Functional combination strategy for prioritization of human miRNA target. Gene. 2014;533(1):132-141.

2015年:

 

23.    Liu W#, Bai X#, Liu Y#, Wang W, Han J, Wang Q, Xu Y, Zhang C, Zhang S, Li X, Ren Z, Zhang J*, Li C (李春权)*. Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case. Sci Rep. 2015 Aug 19;5:13192. SCI影响因子IF=5.2

24.    Feng L#, Xu Y#, Zhang Y#, Sun Z, Han J, Zhang C, Yang H, Shang D, Su F, Shi X, Li S, Li C (李春权) *, Li X*. Subpathway-GMir: identifying miRNA-mediated metabolic subpathways by integrating condition-specific genes, microRNAs, and pathway topologies. Oncotarget. 2015 Oct 12. doi: 10.18632/oncotarget.5341. SCI影响因子IF=5.0

25.    Han J#, Shi X#, Zhang Y#, Xu Y, Jiang Y, Zhang C, Feng L, Yang H, Shang D, Sun Z, Su F, Li C (李春权) *, Li X*. ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis. Sci Rep. 2015 Aug 12;5:13044. doi: 10.1038/srep13044. SCI影响因子IF=5.2

26.    Yao Q#, Xu Y#, Yang H, Shang D, Zhang C, Zhang Y, Sun Z, Shi X, Feng L, Han J, Su F, Li C (李春权) *, Li X*. Global Prioritization of Disease Candidate Metabolites Based on a Multi-omics Composite Network. Sci Rep. 2015 Nov 24;5:17201. SCI影响因子IF=5.2

27.    Han J#, Li C (李春权)#, Yang H#, Xu Y, Zhang C, Ma J, Shi X, Liu W, Shang D, Yao Q, Zhang Y, Su F, Feng L, Li X*. A novel dysregulated pathway-identification analysis based on global influence of within-pathway effects and crosstalk between pathways. Journal of the Royal Society Interface. 2015 Jan 6;12(102):20140937.

28.    Lv W#, Wang Q#, Chen H#, Jiang Y#, Zheng J, Shi M, Xu Y, Han J, Li C (李春权) *, Zhang R*. Prioritization of rheumatoid arthritis risk subpathways based on global immune subpathway interaction network and random walk strategy. Mol Biosyst. 2015 Oct 13;11(11):2986-97.

29.    Liu W#, Wang Q#, Zhao J, Zhang C, Liu Y, Zhang J, Bai X, Li X, Feng H, Liao M, Wang W*, Li C (李春权)*. Integration of pathway structure information into a reweighted partial Cox regression approach for survival analysis on high-dimensional gene expression data. Mol Biosyst. 2015 Jul;11(7):1876-86.

30.    Zhang J#, Wang Y#, Shang D#, Yu F, Liu W, Zhang Y, Feng C, Wang Q, Xu Y, Liu Y, Bai X, Li X, Li C (李春权)*. Characterizing and optimizing human anticancer drug targets based on topological properties in the context of biological pathways. J Biomed Inform. 2015 Apr;54:132-140.

31.    Shang D#, Yang H#, Xu Y, Yao Q, Zhou W, Shi X, Han J, Su F, Su B, Zhang C, Li C (李春权)*, Li X*. A global view of network of lncRNAs and their binding proteins. Mol Biosyst. 2015 Feb;11(2):656-663.

32.    Deng L, Xu Y, Zhang C, Yao Q, Feng L, Li C (李春权)*. A network-based strategy from the global perspective for identification of risk pathways in complex diseases. Prog Biochem Biophys. 2015 Jan 15;42(3):11.

33.    Zhang C#, Li C (李春权)#, Xu Y#, Feng L, Shang D, Yang X, Han J, Sun Z, Li Y*, Li X*. Integrative analysis of lung development-cancer expression associations reveals the roles of signatures with inverse expression patterns. Mol Biosyst. 2015 May; PubMed PMID: 25720795.

34.    Chen X, Wang Y, Wang P, Lian B, Li C (李春权), Wang J, Li X, Jiang W. Systematic Analysis of the Associations between Adverse Drug Reactions and Pathways. Biomed Res Int. 2015;2015:670949.

35.    Zhang Y, Liu W, Xu Y, Li C (李春权), Wang Y, Yang H, Zhang C, Su F, Li Y*, Li X*. Identification of subtype specific miRNA-mRNA functional regulatory modules in matched miRNA-mRNA expression data: multiple myeloma as a case. Biomed Res Int. 2015 Mar 19;2015:501262.

2016年:

 

36.    Song C#, Zhang J#, Liu Y, Pan H, Qi HP, Cao YG, Zhao JM, Li S, Guo J, Sun HL*, Li CQ (李春权)*. Construction and analysis of cardiac hypertrophy-associated lncRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in cardiac hypertrophy. Oncotarget. 2016 Mar 8;7(10):10827-40. SCI影响因子IF=5.0

37.    Feng C#, Zhang J#, Li X#, Ai B, Han J, Wang Q, Wei T, Xu Y, Li M, Li S, Song C, Li C (李春权)*. Subpathway-CorSP: Identification of metabolic subpathways via integrating expression correlations and topological features between metabolites and genes of interest within pathways. Sci Rep. 2016 Sep 14;6:33262. SCI影响因子IF=5.2

38.    Li S, Xu Y, Sun Z, Feng L, Shang D, Zhang C, Shi X, Han J, Su F, Yang H, Zhao J, Song C, Zhang Y, Li C (李春权)*, Li X*. Identification of a lncRNA involved functional module for esophageal cancer subtypes. Mol Biosyst. 2016 Aug 19. PubMed PMID: 27539139.

39.    Zhao J#, Li X#,Yao Q#, Li M, Zhang J, Ai B, Liu W, Wang Q, Feng C, Liu Y, Bai X, Song C, Li S, Li E, Xu L*, Li C (李春权)*. RWCFusion: identifying phenotype-specific cancer driver gene fusions based on fusion pair random walk scoring method. Oncotarget. 2016 Aug 5. PubMed PMID: 27506935. SCI影响因子IF=5.0

40.    Shi X#, Xu Y#, Zhang C, Feng L, Sun Z, Han J, Su F, Zhang Y*, Li C (李春权)*, Li X*. Subpathway-LNCE: Identify dysfunctional subpathways competitively regulated by lncRNAs through integrating lncRNA-mRNA expression profile and pathway topologies. Oncotarget. 2016 Sep 13. PubMed PMID:27634882. SCI影响因子IF=5.0

41.    Han J#, Liu S#, Zhang Y#, Xu Y, Jiang Y, Zhang C, Li C (李春权)*, Li X*. MiRSEA: Discovering the pathways regulated by dysfunctional MicroRNAs. Oncotarget. 2016 Jul 26. PubMed PMID: 27474169. SCI影响因子IF=5.0

42.    Guo JC, Li CQ(李春权), Wang QY, Zhao JM, Ding JY, Li EM*, Xu LY*. Protein-coding genes combined with long non-coding RNAs predict prognosis in esophageal squamous cell carcinoma patients as a novel clinical multi-dimensional signature. Mol Biosyst. 2016 Sep 23. PubMed PMID: 27714034.

43.    Zou HY, Lv GQ, Dai LH, Zhan XH, Jiao JW, Liao LD, Zhou TM, Li CQ (李春权), Wu BL, Xu LY*, Li EM*. A truncated splice variant of human lysyl oxidase-like 2 promotes migration and invasion in esophageal squamous cell carcinoma. Int J Biochem Cell Biol. 2016 Jun;75:85-98.

2017年:

 

44.    Han J, Liu S, Sun Z, Zhang Y, Zhang F, Zhang C, Shang D, Yang H, Su F, Xu Y,Li C, Ren H, Li X. LncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method. Sci Rep. 2017 Apr 20;7:46566.

45.    C-Q Li, G-W Huang, Z-Y Wu, Y-J Xu, X-C Li, Y-J Xue, Y Zhu, J-M Zhao, M Li, J Zhang, J-Y Wu, F Lei, Q-Y Wang, S Li, C-P Zheng, B Ai, Z-D Tang, C-C Feng, L-D Liao, S-H Wang, J-H Shen, Y-J Liu, X-F Bai, J-Z He, H-H Cao, B-L Wu, M-R Wang, D-C Lin, HP Koeffler, L-D Wang, X Li, E-M Li and L-Y Xu1Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma. Oncogenesis 2017 6, e297; doi:10.1038/oncsis.

 

 

 

 


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版权所有:哈尔滨医科大学大庆校区
地址:黑龙江省大庆市高新区新阳路39
黑 ICP 备13001430号-1